Vaginal lubrication: Uses, benefits, types, and side effects Primarily caused by declining estrogen levels, it can result in discomfort, pain during intercourse, and an increased risk of vaginal infections. Less estrogen results in lower blood flow and lubrication, causing thinning Vaginal dryness is a common condition that occurs when the tissues of the vagina don't get enough natural lubrication. It can make intimacy uncomfortable and may sometimes cause itching or burning. Understanding The Low Down on Lube