Editor's Picks: Vaginal Moisturizers To Treat Dryness The Best Lubricants for Vaginal Dryness Mayo Clinic Q and A: Treatments for vaginal atrophy can prevent complications Mayo Clinic News Network Vaginal dryness is often caused by hormonal shifts during menopause, breastfeeding, or periods of low estrogen. Lifestyle factors such as stress, smoking, and the use of certain medications like antihistamines also contribute